Malaria Full-Length cDNA Project (P.falciparum)
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Last Updated (September 15, 2003)

About this Database
Malaria Full-Length cDNA project

1-2.Malaria cDNA Project

1-2-1. Complex Life Cycle of Malaria Parasite

The life of the plasmodium passes in two hosts, a vertebrate and a mosquito. When ana infected female Anopheles mosquito bites a human, infective sporozoites are injected into the human bloodstream.

Complex Life Cycle of Malaria Parasite Within 30 minutes these slender-form parasites invade the human hepatocytes, where they start multiplication and produce thousands of merozoites within a week (exoerythocytic schizogony). When the multinucleate schizont ruptures, the released merozoites enter red blood cells, in which they undergo a second phase of multiplication (erythrocytic schizogony) and form about 20 merozoites. They can infect new red blood cells and this process can be repeated many times. Some merozoites develop into sexual-stage gametocytes, i.e., female macrogametocytes and male microgametocytes. These are taken up by a mosquito. In the midgut, a microgametocyte undergoes a process of maturation that results in the production of eight sperm-like microgametes (exflagellation). They fertilize a mature macrogamete, forming a zygote. The zygote becomes elongated and active and is called an ookinete. The ookinete penetrates the gut wall and comes to lie on the outer surface of the gut but beneath the outer covering of that organ, where it forms an oocyst. The oocysts grow and produce thousands of sporozoites (sporogony). With the rupture of the oocysts, sporozoites are liberated into the body cavity and migrate to the salivary glands, where they wait until a second bite starts the infection cycle again.

  1. Background
  2. Construction of Malaria Full-Length cDNA Library
  3. Current Status
  4. Experimental Procedures

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